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Cagrilintide had one of the lowest GI odds ratios among incretin-class compounds in a 2025 network meta-analysis, but combination GI burden has not been formally quantified

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It exceeds many GLP-1 therapies that have been on the market for years

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The raw material itself presents several technical challenges in pharmacological evaluation and safety management

Oral administration: 0.5-1 mg daily to compensate for lower bioavailability compared to injection